SYNTHESIS OF SOME NEW THIADIAZOLYL-THIAZOLIDIN-4-ONE DERIVATIVES AND BIOLOGICAL EVALUATION FOR IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY
Pragya Nayak*, Monica Kachroo and Priti Gupta
ABSTRACT
4- Thiazolidinones are important members of heterocyclic compounds It contains sulfur and nitrogen along with carbonyl functional group arranged in a saturated heterocyclic ring system which incorporates many biological activities such as anti-inflammatory, antioxidant, antitubercular, antibacterial activities. It has been considered as a magic moiety by many researchers because of its important contribution in the field of drug discovery and its property of possessing several various types of biological activities including antitumor activity. It has been a nucleus of interest because of its usefulness as intermediate for the synthesis of many new heterocyclic compounds. In the present study, an attempt has been made to synthesize 2,4-substituted-1,3-thiazolidin-4-one derivatives by cyclisation of schiff base derivatives. The newly synthesized thiazolidinone derivatives have been characterized by UV, IR, 1HNMR, 13CNMR, Mass spectra and elemental analysis and evaluated for their in-vitro anti-inflammatory and antioxidant activities. It was found that the derivatives containing methyl substitution has exhibited good anti-inflammatory and antioxidant activity at low concentrations as compared to the standard drugs.
Keywords: Thiadiazole, 1,3-Thiazolidin-4-one, Antioxidant, anti-inflammatory.
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