European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIDIABETIC STUDY OF CU(II) AND FE(III) COMPLEXES OF GLIMEPIRIDE

Suman Malik*, Seema Saini and Bharti Jain

ABSTRACT

Pure glimepiride 1-(p-(2-(3-ethyle-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl) sulfonyl)-3-(trans-4-methylcyclohexyl) urea is a third generation hypoglycemic sulfonylurea which is useful in the treatment of non insulin dependent diabetes mellitus (NIDDM) Glimepiride is a white crystalline powder, relatively insoluble in water but highly permeable (class-II) drugs the rate of oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Metal complex of glimepiride has been synthesized by reaction with Cu(II) and Fe(III) in the form of its chloride. The biological activity of many drugs has been shown to be enhanced on complexation with metal ions, hence promoting their use in pharmacology. For the structure elucidation of these complexes “monovariation method” has been used to ascertain the ligand –metal ratio in the complex. The molecular formula are [Cu(C24H34N4O5S)2 (H2O)2] and [Fe(C24H34N4O5S)2 (H2O)2]. The ratio of complex formation with the above metal was further confirmed conductometrically using Job’s method of continuous variation as modified by turner and Anderson.

Keywords: Glimepiride, antidiabetic, glimepiride, spectroscopy, metal salts.