Abstract
IMPORTANCE OF HIGH VIRAL LOAD INDICATORS AS A FACTOR OF PROGRESSION OF CHRONIC HEPATITIS B TO LIVER CIRRHOSIS

*Dr. Aziza Khikmatullaeva, Muazzam Abdukadirova, Nargiz Ibadullaeva, Mukhayyo Asilova, Nataliya Kan

ABSTRACT

There is no reliable information about the effect of viral load on the outcome of chronic hepatitis B. To determine the significance of high viral load as a prognostic marker of the development of LC, we conducted an analysis of medical records of 65 patients with hepatitis B virus, who were on dispensary records for at least 5 years and annually donated blood for the quantitative determination of HBV DNA. There were patients aged 35-65 years, 30 men (52.7%) and 25 women (47.3%). All of them were naive patients who had not previously received antiviral treatment. There is a relationship between HBV DNA and the progression of chronic hepatitis B to LC. The risk of LC increases with the increase in viral load.

Keywords: Chronic hepatitis B, hepatitis B virus, liver cirrhosis, viral load, polymerase chain reaction.


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