European Journal of Biomedical and Pharmaceutical Sciences

CARDIOPROTECTIVE EFFECT OF CARDIOSPERMUM HALICACABUM ON ISOPROTERENOL INDUCED CARDIAC HYPERTROPHIC RATS

Doss V. A.*, Vineetha Krishnamoorthy and Dharaniyambigai Kuberapandian

ABSTRACT

Cardiac hypertrophy is regarded as a compensation mechanism to overcome the increased workload when the stress or injury is transient and turns detrimental on chronic conditions. The cardioprotective potential of the aqueous extract of Cardiospermum halicacabum was evaluated against cardiac hypertrophy induced by isoproterenol in male Albino Wistar rats. Isoproterenol (10 mg/kg b.w., subcutaneous., 7 days) induced cardiac hypertrophy in experimental rats which were simultaneously treated with the standard drug, Losartan (50 mg/kg b.w., oral.,7 days) and plant extract of C.halicacabum (400 mg/kg body weight for 7 days). Biochemical estimations of glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase [SGOT], serum glutamate pyruvate transaminase [SGPT], lactate dehydrogenase [LDH] and enzymic antioxidants (SOD, catalase, glutathione peroxidase) in serum and heart tissues thus collected followed by histopathological analysis at the end of 7 days. Isoproterenol administered rats exhibited detrimental values of biochemical parameters and antioxidants which were significantly (P<0.05) restored toward normal level by the treatment of Cardiospermum halicacabum which also had similar effect at the histological level. Hence treatment with Cardiospermum halicacabum extract showed curative effect in isoproterenol administered rats.

Keywords: Cardiac hypertrophy, Isoproterenol, Losartan, Cardiospermum halicacabum.