A STUDY OF EFFICACY OF 0.05% CYCLOSPORINE EYE DROPS IN CHRONIC DRY EYE DISEASE
Zeenat Fatima, Rakesh Chandra Chaurasia, Satya Prakash Singh
ABSTRACT
Objective: The aim of this study was to evaluate the efficacy of Cyclosporine ophthalmic emulsion in patients with chronic dry eye disease. Methods: This was a single centred, open label, 3 months prospective study. Patients with unilateral or bilateral dry eye disease and an ocular surface disease index score >12, atleast one eye with schirmer score <5mm and TBUT <10 s were enrolled in the study. Cyclosporine A 0.03% eye ointment was instilled twice daily for three months in the affected eye. The primary efficacy outcome was Schirmer score after 3 months. The secondary outcomes were TBUT, OSDI score and adverse drug reactions. Results: A total of 27 patients with the mean age of 52.39 ± 8.10 were enrolled and 23 patients completed the study. After 3 months significant improvement was seen in schirmer tear test, 52.17 % patients showed ≥ 5 mm improvement and 21.8% patients showed ≥ 10 mm improvement in Schirmer score. Mean tear film breakup time also showed significant improvement after 3 months (p <0.0001). Patients also reported significant improvement in ocular discomfort and dry eye symptoms suggested by decrease in OSDI score (p < 0.001). No patients discontinued treatment because of minor ocular adverse reactions. Conclusion: Dry eye patients demonstrated improvement in schirmer score, TBUT and OSDI score in patients of Chronic dry eye disease after 3 months of treatment with Cyclosporine A 0.05% ophthalmic emulsion.
Keywords: Cyclosporine ophthalmic solution,Schirmer score,TBUT,OSDI Score.
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