ASSOCIATION OF HELICOBACTER PYLORI INFECTION AND VITAMIN B12 LEVEL AMONG SUDANESE PATIENTS IN KHARTOUM STATE-2018
Ola A. Mohammed, Mohammed M. Mohammed, Rimaz A. Mohammed, Zaienab S. Abdulaziz and Tarig A. M. Hamid*
ABSTRACT
Helicobacter pylori is an organism that is reported to cause deficiency of vitamin B12 by producing gastritis and peptic disease which results in vitamin B12 malabsorption, the exact mechanism is unknown but the suggested mechanisms are that H. pylori decreases the hydrochloric acid content of the gastric juice which effect on vitamin B12 absorption. A case-control study was conducted in the Military hospital, Khartoum state, Sudan, where H. pylori infection was diagnosed. Study done during Feb to April 2018 and included 80 samples, 50 of these samples were collected from patient diagnosed with H. pylori as a case group, and 30 samples were collected from apparently healthy individuals as control group. A total of 3 ml venous blood samples were collected to obtain Serum used for estimation of serum B12 level by competitive Immunoluminometric assay among tow studied group. The present study showed that There was a significant decrease of S. B12 level among case compare with control group with a mean (297.7 ± 289.6, 569.8 ± 171.5) respectively (P; 0.007). Also show there is no correlation between S. B12 level in H. pylori patient compare with gender, H. pylori infection duration, other disease, bloody stool and treatment with P. value (0.949, 0.158, 0.684, 0.339, 0146) respectively. The study concluded that Helicobacter pylori has a significant effect on vitamin B12 level and H. pylori infection is a cause of vitamin B12 deficiency. Indicate there is an association between S.B12 deficiency and H. pylori infection.
Keywords: Helicobacter pylori is malabsorption, Immunoluminometric and H. pylori infection.
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