European Journal of Biomedical and Pharmaceutical Sciences

SPERMS QUALITY OF MICE DECREASED BY SEED EXTRACT OF PAPAYA (CARICA PAPAYA L.)

Hendri Busman, Nuning Nurcahyani, Sutyarso, Eka Ratna Susmala Dewi and Mohammad Kanedi*

ABSTRACT

Objective: To enrich new evidence about the anti-fertility activity of seeds extract of papaya (Carica papaya L.) in test animals, especially mice. Methodology: Male mice (n=20) were grouped into four. The first group received only distilled water containing 1% CMC as the control. Group 2, 3 and 4 consecutively received papaya seeds extract of 2, 4 and 8 mg/40 g body weight. All treatment administered orally using stomach sonde once daily for 35 days. Study parameters assessed were sperm motility, viability, and normal morphology. Results: In comparison to control group, mice injected with papaya seeds extract at the doses of 4 mg or more significantly decreased motility and normal morphology of spermatozoa. In addition, papaya seeds extract of all doses were significantly decreased percentage of sperm viability. Conclusion: Papaya seeds extract is potential to be used as male anti-fertility agent.

Keywords: Carica papaya, contraceptives, papaya seeds, antifertility, sperm quality.