European Journal of Biomedical and Pharmaceutical Sciences

ROLE OF ENDOTHELIAL DYSFUNCTION IN TYPE 2 DIABETES MELLITUS & CARDIOVASCULAR DISEASE

*Dr. R. Dhananjayan

ABSTRACT

Type 2 diabetes mellitus is associated with systemic insulin resistance, which promotes hyperglycemia and dyslipidaemia. These metabolic abnormalities account for increased cardiovascular risk. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis and is associated with Type 2 diabetes mellitus and insulin resistance in experimental and clinical studies. Cardiovascular disease is a major complication of diabetes mellitus, and improved strategies for prevention and treatment are needed. Endothelial dysfunction contributes to the pathogenesis and clinical expression of atherosclerosis in diabetes mellitus. The diabetic vascular disease develops endothelial dysfunction, which is characterized by a loss of NO and development of a pro-inflammatory vascular phenotype that promotes atherosclerosis and cardiovascular disease.

Keywords: Type 2 diabetes mellitus atherosclerosis and cardiovascular disease.