Abstract
RELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR-1 AND CYSTATIN-C IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Yasser I. Kandil*, Ahmed I. Abulsoud, Tarek M. Salman, Maha M. Akl, Ragaa R. Mohamed

ABSTRACT

Background: Chronic kidney disease (CKD) is a life-threatening condition characterized by progressive and irreversible loss of renal function. Due to its high prevalence and associated mortality, CKD is an important human and social burden. Cystatin-C, an endogenous protein produced by nucleated cells, is a promising biomarker to estimate the glomerular filtration. Insulin-like growth factor-1 (IGF-1) has been associated different disorders that affect renal functions, it is suggested that increasing levels of serum IGF-1 will be positively associated with CKD and that IGF-1 might be a predictor of CKD. Objective: To examine the relationship between serum levels of IGF-1 and cystatin-C in different stages of CKD. Patients and Methods: seventy patients with CKD and twelve healthy controls were included in this study. The patients were subclassified into five groups according to their CKD stages based on their eGFR. Urea, creatinine, albumin, sodium, potassium, calcium, and phosphorus were measured spectrophotometerically. Also, serum cystatin-C was measured by ELISA and IGF-1 by chemiluminescence technique. Results: a highly significant increase in serum cystatin-C level in all stages of CKD when compared to control group. There was a highly significant increase in serum IGF-1 level between patients with CKD-4 and CKD-5 when compared to the control group where or the other stages of CKD. Finally, IGF-1 showed a highly positive correlation to cystatin-C. Conclusion: serum levels of both cystatin-C and IGF-1 are increased among the different stages of CKD and they are positively correlated.

Keywords: Chronic kidney disease, Cystatin-C, Insulin-like growth factor-1.


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