European Journal of Biomedical and Pharmaceutical Sciences

COMPARATIVE ANALYSIS OF ATHEROGENIC INDEX OF PLASMA AND BODY MASS INDEX IN TYPE II DIABETES MELLITUS PATIENTS

*Sangeeta B. Trimbake, Prachi S. Chikhalikar, Dr. Shilpa A. Pratinidhi

ABSTRACT

Background: Diabetes mellitus is the leading cause of mortality and morbidity world over. Cardiovascular diseases due to diabetes mellitus are related to deranged lipid profile. Hence it is important to check lipid profile in diabetics. And atherogenic index of the plasma is a good indicator to assess lipid profile and it is calculated through the formula of log[TG/HDL-c]. Obese and overweight people are at higher risk for developing diabetes and cardiovascular complications. Hence it is important to check body mass index and atherogenic index of plasma of diabetic patients and if there are cases with deranged lipid profiles they should be treated as early as possible to prevent future complications. Objectives: To find out co-relation between body mass index & atherogenic index in type II diabetes mellitus patients. Study design: A Case control observational study. Settings: Central Clinical Laboratory of MIMER Medical college, Talegoan Dabhade, Pune & Department of biochemistry, Talegoan Dabhade, Pune. Data Sources& Analysis: Serum lipid levels & BMI of 66 subjects [33 were cases & 33 were age and sex matched controls] was estimated and analyzed and correlation between them was observed. Results: Diabetic patients showed higher values of total cholesterol of 182.54 ± 37.95 mg/dl, TG 145.45±25.24 mg/dl, LDL cholesterol 105.66 ± 26mg/dl, and lower values of HDL cholesterol 43.09 ± 8.85 mg/dl, as compared to controls with total cholesterol levels of 170 ± 36.45 mg/dl, TG levels 66.30 ± 16.96 mg/dl, LDL 99.97 ± 23.82 mg/dl, and HDL 44.33 ± 15.96 mg/dl. Average atherogenic index and BMI values were 0.51 ±0.14, 27.78 ± 2.26 and 0.17 ± 0.15, 23.46 ± 2.77 in cases and controls respectively. Conclusion: Diabetics showed higher values of atherogenic index and BMI as compared to normal controls and there was a positive correlation in between BMI and A.I. but it was not significant.

Keywords: atherogenic index, BMI, Diabetes Mellitus, Risk of cardiovascular diseases.