European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF HYPOLIPIDEMIC AND INSULIN RESISTANCE EFFECTS OF HYDRO-ALCOHOLIC EXTRACT OF RHIZOMES OF NELUMBO NUCIFERA IN EXPERIMENTAL RATS

Rahul Saxena*, Megha Chouhan and Narendra Nagar

ABSTRACT

Objectives: The present study was designed to evaluate the hypolipidemic and insulin resistance effects of hydro-alcoholic extract of rhizomes of Nelumbo nucifera in experimental rats by HFHS diet induce model. Materials and Methods: Following Institutional Animal Ethics Committee permission, the study was conducted in Wistar rats (180-200 g). The model was developed using a high fat (Vanaspati ghee: coconut oil, 3:1) oral diet along with 25% fructose (high sugar) added in drinking water over a period of 6 weeks. Atorvastatin (2.1 mg/kg/day), metformin (2.7 mg/kg/day) and NNHE (300 mg/kg/day) were administered 3 weeks after initiation of HFHS diet and continued for another 3 weeks. During the study period food and water intake, body weight, lipid profile, blood glucose level, insulin level was assayed. Results: HFHS diet significantly increase the Blood glucose, Insulin & lipid profile. Treatment of standards & test drug decrease the blood glucose level, insulin level & also lipid profile parameters. Therefore, confirming the efficacy of model

Keywords: Coronary heart disease, high fat, high sugar, hyperlipidaemia, insulin resistance, Nelumbo nucifera.