European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING ORO-DISPERSIBLE PELLETS OF MECLIZINE HCL USING EXTRUSION AND SPHERONIZATION TECHNIQUE

K. Jesindha Beyatricks*, Jilu Mohan and Manvitha K.

ABSTRACT

Among all the dosage forms conventional forms are convenient way to administer, and even more easy when preparation like Oro dispersible tablets or pellets administered which directly get into systemic circulations. Pellatization is a technique which achieves control release rate of drugs when coated with suitable polymers. For formulation, drug-excipients incompatabilities were carried out by FTIR and DSC. Among all the F2(SD-1:2) was having std results for particle size (2.57), Bulk density(0.406±0.004), Tapped density(0.498±0.003), Cars index(8.535±0.002), Hausners ratio(1.023±0.001). Pellet were evaluated for F2, Pellet size(0.80±0.015mm), Disintegration(50.9±0.020sec), Wetting time(4.0min), Friability(0.7±0.036%). In vitro dissolution test reveals the release increase from 50% to a maximum of almost 100% for 30 min. The release is in the following order of Formulation F2> F1> F5> F3> F4.

Keywords: Oro dispersible, FTIR, DSC, Pellet, Disintegration.