EXPRESSION OF APCTUMOR SUPPRESSOR GENE IN COLORECTAL CANCER: RETROSPECTIVE STUDY
Menha Swellam*, Hatem El Mezean and Eman Sayed
ABSTRACT
Background: Despite the advances in diagnosis of colorectal cancer it is still the third malignancy worldwide. Adenomatous polyposis coli (APC) gene responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary disease, characterized withhundreds to thousands of adenomatous polyps in colon and rectum. The majority of both sporadic and familial forms of adenomatous polyposis (FAP) in colorectal cancer (CRC)originates from inactivation of APC (Adenomatous Polyposis Coli) tumor suppressor gene. Authors aimed to investigate the clinical significance of APC in colorectal cancer progression. Materials and methods: Expression of APC was detected in 50 formalin fixed paraffin using quantitative PCR (QPCR) and their levels were analyzed versus clinicopathological factors and the overall survival (OS) of CRC patients. Results: Significant relation was reported young female and CRC as compared to their counterparts from male individuals. APC Expression was increased significantly with young CRC and reported significant correlation with advanced stage and high grade tumors. Worse OS was reported among patients with decreased APC expression. Conclusion: APC expression was significantly related to differential grading and patient's outcome thus pointing out their potential role as predictive markers for CRC prognosis.
Keywords: Colorectal cancer; tumor suppressor genes; APC; progression, prediction.
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