European Journal of Biomedical and Pharmaceutical Sciences

ANTI STRESS ACTIVITY OF TINOSPORA CARDIFOLIA IN ALBINO RATS BY ORAL ROUTE

Mukkera Naga Malleswari*, D. Haritha Goud and Nandimandala Venkata Kishore Raju

ABSTRACT

Present study was undertaken to evaluate the antistress activity of Tinospora Cardifolia root. The antistress effect of a seven day treatment (100 mg/kg, 200 mg/kg,p.o) of the aqueous and methanolic extract suspensions of root of tinospora cardifolia was evaluated by using swimming endurance test and biochemical changes in the cold restraint stress model. Extract treated animals showed a decreased in immobility time and an increase in mobility time in swimming endurance respectively. Pretreated extract significantly ameliorated the cold stress induced variations in biochemical levels such as increased plasma cholesterol, triglyceride, glucose, total protein and cortisol. The findings of the present investigations indicate that the Tinospora cardifolia has significant antistress activity, which may be due to the increased resistance, nonspecifically against all experimental stress conditions.

Keywords: Triglycerides, cholesterol, antistress activity, swimming endurance test.