European Journal of Biomedical and Pharmaceutical Sciences

HEPATOPROTECTIVE ACTIVITY OF BRASSICA OLERACEA IN PARACETAMOL INTOXICATED ALBINO RATS

K. Durgadevi, T. Abarna, R. Gowri and V. Ramamurthy*

ABSTRACT

Hepatoprotective activity of ethanolic extract of Brassica oleracea L. var. Italica flower was studied against paracetamol induced acute hepatotoxicity in albino rats. We studied the effect of B. oleracea on serum glutathione, protein, serum marker enzymes, serum bilirubin, and thiobarbutiric acid reactive substances against paracetamol induced damage in rats has been studied to find out the possible mechanism of hepatoprotection. Pre and post-treatment with extract showed a dose-dependent reduction of paracetamol induced rats were elevated levels of enzyme activity with parallel increase in total protein and bilirubin, indicating the extract could preserve the normal functional status of the liver. The weight of the organs such as liver, heart, lung, spleen and kidney in paracetamol induced experimental animals administered with B. oleracea showed an increase over paracetamol control group.

Keywords: Hepatoprotective activity, Brassica oleracea, hepatotoxicity, enzyme activity, Biochemical studies.