ASSESSMENT OF G6PD AND CBC PARAMETERS AMONG SUDANESE PATIENTS WITH TYPE 2 DIABETES MELLITUS
Eltaher A. E. Ahmed*, Mahmoud I. O. Hamad, Mohammed B. Omer and Amira A. K. Humida
ABSTRACT
Back ground: Diabetes mellitus (DM) is a common and complicated disease with increasing prevalence especially in developing countries. Complications of DM impose heavy health and financial burden on society. The definition of diabetes mellitus has recently changed considerably. This condition is now defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and/or action. Objective: This study aimed to assess the G6PD level and CBC indices among Sudanese patients with D.M. Materials and method: This was a prospective case-control hospital-based study conducted in Modern Medical Center in Khartoum, Sudan from December 2016- May 2017. This study included sixty diabetic patients as cases, control group included (40) non- diabetic volunteers. CBC and G6PD were assessed among both the case and control groups and frequency of abnormal result was determined. Results: In this study we found that the level of G6PD was low in all the sixty patients (mean, SD: 1279.00±680) and was normal in the control group (mean, SD: 1989.35±503.19) with a statistically significant difference (p.value of 0.00). Also found that there was insignificant correlation between G6PD level and Hb level with a p-value of (0.594). Conclusion: This study concluded that G6PD level was significantly decreased in diabetic patients when compared to control individuals, there was strong association between DM and G6PD deficiency, diabetic hyperglycemia may lead to serious complications and decrease G6PD activity. Also this study concluded that there was no significant difference in CBC parameters between different case and control groups.
Keywords: Complete blood count (CBC), Diabetes mellitus (DM), (G6PD), Hemoglobin (Hb).
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