COMPARISON BETWEEN THE METRONIDAZOLE GEL 0.75% AND PERMETHRIN CREAM 2.5% IN THE TOPICAL TREATMENT OF ROSACEA
*Dr. Noor J. Mahdi, Dr. Ali H. Hafedh and Dr. Wesam A. Jawad
ABSTRACT
A comparative clinical study was conducted to evaluate the efficacy and safety of metronidazole gel 0.75% and permethrin cream 2.5% in the treatment of rosacea at the Department of Dermatology and Venereology in Al-Kindy teaching hospital during the period from July 2016 to March 2017. Sixty-six patients, who diagnosed to have rosacea on clinical ground, were enrolled in this study. Patients randomly divided into two groups: The first group included 36 patients subjected to treatment with metronidazole gel and the second group included 30 patients subjected to treatment with permethrin cream. All patients were instructed to use the treatment twice daily for 2 months. Results revealed that the patients treated with metronidazole gel showed a significant improvement in the inflammatory lesions counts after 2 weeks of treatment. The improvement of the Erythem was slight which indicated the need of a longer time to show significant response. Effect of metronidazole gel on telangiectasia is mild, show slight improvement. Concerning the Patients treated with permethrin cream results showed an improvement in the inflammatory lesions counts and erythema but statistically not significant. It had no effect on telangiectasia. In conclusion: However, metronidazole gel and permethrin cream can be used for treatment of rosacea, but the metronidazole gel 0.75% is more effective and safe than permethrin cream 2.5% and has infrequent side effects.
Keywords: Metronidazole permethrin rosacea.
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