Abstract
HYPERCHOLESTEROLEMIA

Jisha Vijayan*, Sruthy S. A., Neethu J., Nithin Manohar R., Babitha M. and Soumya R. V.

ABSTRACT

Although the incidence of atherosclerosis related vascular disease events is declining in the united state, coronary heart disease ischemic cerebrovascular disease and peripheral disease still account for the majority of morbidity and mortality among middle aged and older adult. Hypercholesterolemia is the major cause of increased atherogenic risk, and both genetic disorder and diet enriched in saturated fat and cholesterol contribute to the elevated level of our population and many other developed countries in world. Recognition of hypercholesterolemia as a risk factor had lead to the development of drugs that reduce cholesterol level. These drugs have been used in well controlled studies of patients with high cholesterol level caused primarily by elevated of low density lipoproteins and these trials indicates CHD mortality reduced by as much as 30% to 40% and the nonfatal events are reduced when patients are treated with moderate dose of hypolipidemic drugs. Hypercholesterolemia is the presence of high level of cholesterol in the blood. It is the form of hyperlipidemia and hyperlipoprotenemia. Cholesterol is a sterol, a sort of fat. It is one of three major classes of lipids which all animal cells utilize to construct their membranes and is thus manufactured by all animal cells. Plant cells do not manufacture cholesterol. it is also precursor of the all steroid hormones, bile acid and vitamin D. cholesterol circulate in the blood stream. It is an essential molecule for the human body. Cholesterol is a molecule from which hormone and steroids are made. it is also used to maintain nerve cells between 75% and 80% of the cholesterol that circulate in a person blood stream is made in that precursor liver. cholesterol is found in animal source of blood. It is not found in animal. Normal blood cholesterol level is a number derived by laboratory analysis. A normal or desirable cholesterol level is defined as less than 200mg of cholesterol per deciliter of blood. Blood cholesterol is considered to be border line when it in the range of 200 to 239mg/dl. Elevated cholesterol is level is 240mg/dl or above. Elevated level cholesterol is considered to be hypercholesterolemia. Since cholesterol is insoluble in water, is transported in the blood plasma within protein particles (lipoprotein). Lipoprotein are classified by their density very low density lipoprotein (VLDL), Intermediate density lipoprotein (IDL), Low density lipoprotein (LDL), High density lipoprotein. All the lipoprotein carry cholesterol, but elevated level of lipoprotein other than HDL(termed non HDL cholesterol), particularly LDL-cholesterol are associated with an increased risk of atherosclerosis and coronary heart disease. In contrast higher levels of HDL cholesterol are protective. Elevated level of non HDL cholesterol and LDL in the blood may be a consequence of diet, obesity inherited (genetic) disease or the presence of other disease such a diabetes under active thyroid. Reducing dietary for recommended to reduce total blood cholesterol and HDL in adults.

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