Abstract
A REVIEW ON NOVEL APPROCHES OF HETEROCYCLIC COMPOUNDS

Dr. Debopratim Dasgupta, Kamallochan Barman*

ABSTRACT

The heterocyclic compound like Quinine shows antimalarial activity and the substitution quinine shows more potent activities in compound like chlorquinine, primaquinine etc. Research shows that ferroquinone and aminoquinone shows high activity against chloroquinone-resistant malaria parasites. The quinazoline derivative drugs like erlotinib, and lapatinib are also important tyrosine kinase inhibitors. And the research studies shows that Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the ATP-binding pocket of target kinases. Lastly the compounds which are SND approved in 2018 having heterocyclic ring. The compounds are Cefditoren pivoxil, Eltrombopag Olamine tablets, Alectinib capsule, Bendamustine Hydrochloride injection, Methotrexate injection prefilled syringe, Sildenafil powder for oral suspension, Febuxostat tablets and Posaconazole injection. They are not only pivotal in the synthesis of drugs, but also form part of the structure of a diversity of drugs, vitamins, natural products and biomolecules. The compounds shows activities like anti malarial, anti neoplastic activity and the compounds that are approved in 2018 have different heterocyclic compound for potency of the compound.

Keywords: Heterocyclic compounds, Pharmaceuticals, heterocyclic ring.


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