European Journal of Biomedical and Pharmaceutical Sciences

PROSTATIC CARCINOMA: CORRELATION OF GLEASON’S SCORE WITH SERUM PSA LEVELS

Rubeena Naz Mohroo* and Swami Ravi

ABSTRACT

Background: Prostate carcinoma is the sixth most common cancer in men and is second leading cause of cancer related death in men. Gleason’s grading system is recommended by World Health Organisation (WHO), is a unique histopathological method for grading prostate cancer based solely on tumour architecture. Prostate specific antigen (PSA) is a protein secreted by both normal and abnormal prostate cells. Objective: The objective of the study was to determine the histopathological features and Gleason grading in Prostatic Carcinoma and to correlate with pre-treatment PSA levels with the Gleason score. Results: Twenty seven cases of prostatic carcinoma were studied. Most of the patients were in age group of 61-70. Median for serum PSA levels were 49.8 ng /ml and P – value < 0.001. Majority cases of cases had Gleason score of 5 – 7 (74.07%). The patients with Gleason Score of 5 – 7 had serum PSA levels >40 ng/ml. Conclusion: It was observed that the levels of serum PSA increased with increasing Gleason grade and score of the tumour.

Keywords: Prostate carcinoma, Gleason score, serum PSA.