ROLE OF IMMATURE RETICULOCYTE FRACTION IN CLASSIFICATION OF HYPOREGENERATIVE ANEMIAS
Dr. Jayanti Nayak and Dr. Pramita Sahu*
ABSTRACT
Anaemia is a global health problem. India has a high prevalence of anaemia. Anemia is categorized to hypo-regenerative anaemias and regenerative anaemias based on the absolute reticulocyte count. The immature reticulocyte fraction (IRF) gives a basic idea about the marrow erythropoietic activity and its response to drugs and therapy at an early stage thereby useful for monitoring therapy by the physicians without seeing the marrow. In our study 312 cases of anemia were studied. The most common cause of hypo-regenerative anemia in our study was found to be megaloblastic anemia with 93 (29.8%) followed by iron deficiency anemia anemia (28.2%). There was no significant difference in Hb and reticulocyte percentages across the anemia groups, p>0.05, but the present study observed a weak but significant correlation while comparing IRF with RT%, ARC and Hb (p<0.05). The conclusion of the present study was, considering the ARC and IRF values along with peripheral smear examination give further clues to the differential diagnosis of anaemia and it can also aid in differentiation of aplastic anaemia from other causes of pancytopenia as true aplastic anaemia cases have zero IRF along with low reticulocyte count.
Keywords: Pancytopenia, Immature Reticulocyte Fraction, Aplastic anemia.
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