European Journal of Biomedical and Pharmaceutical Sciences

A PROSPECTIVE OBSERVATIONAL STUDY TO EVALUATE THE PRESCRIPTION PATTERN OF PIPERACILLIN/ TAZOBACTAM IN UTI AND IT’S RECURRENCE RATE IN PATIENTS WITH OR WITHOUT DIABETES MELLITUS

*Prof. Dr. Mathew George, Prof. Dr. Lincy Joseph, Christy K Jose, Elena Cheruvil and Praise Sebastian

ABSTRACT

Background: Many antibiotics have been developed for UTI but showed resistance and recurrence rate, here we looks for the prescription pattern of Piperacillin Tazobactam. Objective: To evaluate the prescription pattern of piperacillin/ tazobactam in uti and it‟s recurrence rate in patients with or without diabetes mellitus. Design, setting and participants: 60 patients having UTI with Piperacillin Tazobactam were identified and followed for two months and a total of 6 month study. Outcome measurement and statistical analysis: Relationship with outcome analysed using simple statistical method. Results and Limitations: This was a short term study. We identified that most of the patients were postmenopausal women and most P\T were empirical therapy and DM is the major cause of recurrence, 18%were the recurrence rate. AKI and sepsis were the most common complications. Quality of life were improved (Since P value is less than 0.01, it is highly significant at 1% level of significance.). Conclusion: DM patients is having higher rate of recurrence. This study also suggests that educational interventions regarding strict control and monitoring of the chronic disease condition help in avoiding recurrence of UTIs. Patient summary: The behaviour of UTI varies considerably. In this paper we look into different recurrence rate in patients.

Keywords: UTI, Prescription, Piperacillin/Tazobactam, Recurrence.