Abstract
PREPARATION AND EVALUATION OF RIZATRIPTAN SUBLINGUAL TABLETS BY USING SUPERDISINTEGRANTS

Geetha Medha*, Dr. T. Mangilal, Dr. M. Ravi Kumar and J. Naveen

ABSTRACT

The present aim of study is to formulate and evaluate Sublingual tablets of Rizatriptan. Super disintegrating agents like Sodium starch glycolate, Gellan gum, and Croscarmellose sodium were employed has to increase the solubility and dissolution rate of the Rizatriptan drug molecule. Formulation of sublingual tablets was carried out by using direct compression method in 8 station rotary punching machine with a 6mm punch for all formulations. The mixture of nine formulations was passed Pre-compression and Post-compression parameters and they passed all the quality control parameters as per IP limits. The FTIR and DSC studies were analyzed for compatibility studies. The F4 formulation was considered as the optimized formulation as it shown maximum amount of release of drug was found to be 99.16% in 8 min. Gellan gum as a super disintegrant shown maximum drug release in the concentration of 10mg in F4 formulation.

Keywords: Rizatriptan, Croscarmellose Sodium, Gellan Gum and Sodium Starch Glycolate.


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