European Journal of Biomedical and Pharmaceutical Sciences

RETROSPECTIVE STUDY OF ANTIMICROBIAL DRUG RESISTANCE PATTERN OF UROPATHOGENS IN A TERTIARY CARE HOSPITAL IN SUB URBAN CHENNAI

Raveendran Praveena* and Chitralekha Saikumar

ABSTRACT

Introduction: Urinary tract infections (UTI) are the most common reason for patients requiring treatment. There is alarming increase in resistance of bacteria to many routinely used antibiotics. Keeping abreast of the current antibiotic resistance pattern would help institute therapy judiciously. Methods: A retrospective study of the culture isolates obtained from urine samples received at the Department of Microbiology, Sree Balaji Medical College Hospital, Chennai, India, was carried out from November 2017 to February 2018. Results: 952urine specimens were received, 28.2% showed significant growth. A total of 230 isolates were used in the analysis. Escherichia coli (51.2%) was the most common Gram-negative bacillus, followed by Klebsiella species (15.3%) and Pseudomonas species (8.8%). The most common Gram-positive organism was Enterococcus. many isolates were resistant to cephalosporins. Resistance to cephalosporins and fluoroquinolones was higher. apart from Klebsiella spp., all other Enterobacteriaceae were susceptible to carbapenems still while fluoroquinolones were also effective. Conclusion: Due to increasing trends of antibiotic resistance, it is better to have knowledge of the pattern of antibiotic resistance developing currently.[1] This will help initiate culture tests prior to treatment with antibiotics.

Keywords: Antibiotic resistance, uropathogens, gram negative bacillus, Chennai.