European Journal of Biomedical and Pharmaceutical Sciences

COMPARISON OF ANTIHYPERTENSIVE EFFECT OF AZILSARTAN WITH TELMISARTAN IN DIABETIC PATIENTS- AN OBSERVATIONAL STUDY

Dange Suresh V.*, Vaid Ritika and Das Sayan

ABSTRACT

Introduction: Despite the availability of effective drugs for hypertension, it remains uncontrolled in majority of patients. Azilsartan, a new antihypertensive drug, has not been studied in diabetic hypertensives. Objective: To study the efficacy of azilsartan in patients of T2DM & HT and compare that with telmisartan. Methods: Adult patients attending the OPD of Dhanashree Hospital, New Sangavi, Pune; suffering from T2DM and HT were studied. They were treated with usual oral anti-diabetic drugs and received either telmisartan 40mg/d or azilsartan 40 mg/d for hypertension. Clinical examination and laboratory parameters were assessed every three monthsover a period of six months. Data obtained were analysed by Student´s t-test and P value < 0.05 was considered as statistically significant. Results: Seventy-one patients were enrolled in the study. Nine were lost during follow-up. Thirty two patients received telmisartan, while 30 were treated with azilsartan. Both the groups were comparable at base-line with respect to clinical & laboratory parameters. Both drugs significantly reduced SBP (152+/-23 vs136 ± 14 mm Hg) and DBP (158+/-25 vs.127 ± 12 mm Hg). Azilsartan was significantly (P<0.05) more effective in reducing the blood pressure than telmisartan. There was no significant difference in the glycaemic and lipid parameters. Both drugs were well tolerated. Conclusion: Azilsartan was significantly more effective than telmisartan as an antihypertensive in T2DM patients.

Keywords: T2DM, Hypertension, Telmisartan, Azilsartan.