Abstract
LIPID PEROXIDATION DAMAGE CAUSED BY HEAVY METAL EXPOSURE IN RESIDENTS OF AN OIL PRODUCING AREA IN BAYELSA, STATE, NIGERIA

Ifenkwe John C.*, Nwanjo Harrison U., Nwosu Dennis C., Solomon Ederi A., Inifuro Samson N. and Ajuru Gospel

ABSTRACT

Blood samples were collected from 200 residents each from Igbeta-Ewoama (Oil Producing Area) and Odi (Non-Oil Producing Area) both in Bayelsa State, Nigeria, to determine the levels of Cadmium, Chromium, Lead, Mercury, Selenium and 8-Iso-Prostagladin F2α. Blood samples were also analyzed for hemoglobin, platelets, white blood cells, prothrombin time and serum concentrations of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, bilirubin, gamma glutamyl transferase, total protein, sodium, potassium, chloride, bicarbonate, creatinine and urea. Residents in Igbeta-Ewoama had the highest blood levels of 8-Iso-Prostagladin F2α, Mercury, Lead, Selenium, Cadmium and Chromium. These concentrations were all significantly different from levels measured in the non-oil producing community at P<0.05. Residents in Igbeta-Ewoama also had the highest mean values of all the measured liver and kidney functions parameters with the exception of albumin, total protein, sodium, chloride and bicarbonate. These parameters were all statistically different at P<0.05. There were significant differences in the levels of hemoglobin, white blood cells and platelets, while the length of bleeding time was prolonged in the residents of Igbeta-Ewoama community. The findings of this study suggest that the probability of occurrence of diseases associated with metal toxicity and oxidative stress induced by lipid peroxidation damage might be higher among people living in the oil producing area.

Keywords: Heavy Metal, Lipid Peroxidation, Oil Producing Area, Spillage, Bioaccumulation and Bayelsa State.


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