European Journal of Biomedical and Pharmaceutical Sciences

DESIGN, FORMULATION, AND EVALUATION OF CARBOPOL 940 AND XANTHAN GUM AS GEL BASES FOR ORAL LOCAL DRUG DELIVERY FOR ORAL MUCOSAL INFECTIOUS DISEASES

*Fatehalrahman F. Magbool, Elamin Ibrahim Elnima, Shayoub M. E. and Elnazeer I. Hamedelniel

ABSTRACT

Local drug delivery systems have been used for a long time; in particular, for the local therapy of diseases affecting the oral cavity. Oral mucosa diseases are among the most common diseases affecting humans, and they can be effectively treated by topical therapeutic approaches. Infectious agents targeting the oral mucosa include viral, fungal and bacterial species. Local drug delivery can provide a more targeted and efficient drug-delivery option than systemic delivery for diseases of the oral mucosa. Oromucosal gels are semi-solid preparations containing one or more active substances intended for administration to the oral cavity and/or the throat to obtain a local or systemic effect. Oral gels should have acceptable physical and chemical parameters and should also be stable over the period of use. The objectives of this study were to design, develop oromucosal gel base formulations for oral local drug delivery for oral mucosal infectious diseases, and optimization of different oral gel bases through pharmaceutical characterization including evaluation of sensory and organoleptic properties as well as physicochemical characteristics.

Keywords: Oromucosal gels, carbopol 940, xanthan gum, physicochemical properties, viscosity, sensory and organoleptic properties.