Abstract
MUCOADHESIVE MICROSPHERES: A PROMISING APPROACH FOR ORAL DRUG DELIVERY

S. S. Dali* and P. Kadu

ABSTRACT

Mucoadhesive microspheres are one of the most promising novel techniques for drug delivery. Mucoadhesive systems offer a sustained drug release method, thus enhancing drug absorption in a site-specific manner. Microspheres have very small sizes and provide efficient carrier capacities. Mucoadhesive systems therefore play a vital role in drug delivery systems. Mucoadhesive microspheres interact with mucous of gastrointestinal tract (GIT) and are considered to be localized or trapped at the adhesive site by retaining a dosage form at the site of action, or systemic delivery by retaining a formulation in intimate contact with the absorption site which may result in prolonged gastric residence time as well as improvement in intimacy of contact with underlying absorptive membrane to achieve better therapeutic performance of drugs. Mucoadhesion is a two-step procedure, and its mechanism can be explained by combining theories of wetting, mechanical interlocking, electronic transfer, adsorption, fracture, and diffusion interpenetration, as deemed suitable. Mucoadhesive microspheres offer added advantages of reliability, safety, specificity, prolonged action, delayed release, and enhanced activity. These systems can be prepared by solvent evaporation, ionotropic gelation, emulsion solvent diffusion, spray drying, and solvent removal. The resulting microspheres are characterized using a number of parameters using in vivo and in vitro techniques. This review article gives an overview of mucoadhesive microspheres, preparation methods, characterization, applications, and recent developments.

Keywords: Microspheres, mucoadhesion, mucoadhesion theories, mucoadhesive polymers and evaluation methods.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT