Abstract
ROLE OF RED GRAPE EXTRACT AGAINST NICOTINE INDUCED CHANGES IN THE LUNG TISSUE OF MALE ALBINO RAT WITH REFERENCE TO AGING

M. Jayachandrudu, P. Muni Lakshmi, S. Kishore, K. Khalindar Basha and K. Chennaiah*

ABSTRACT

A grape (Vitis vinifera) is commercial juice product have been applied in medical research studies, showing potential benefits against the diseases. Nicotine, a major toxic component of cigarette smoking, has long been recognized to result in oxidative stress by inducing the generation of reactive oxygen species in the lung tissue. Wistar strain male albino rats were used in the present study, rats were divided into 4 groups of six in each group i) Normal Control (NC) (Control rats received 0.9% saline); ii) Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months); iii) Red Grape extract treated (RGEt) (red grape extract 25mg/kg body weight (after the standardization) via orogastric tube for a period of 2 months.); IV) Nicotine + Red Grape extract treatment (Nt+RGEt) as a mentioned in above Group II and Group III. The animals were sacrificed after 24 hrs after the last treatment by cervical dislocation and isolated the lung tissue. The levels of Succinate dehydrogenase (SDH), Isocitrate dehydrogenase (ICDH) and Malate dehydrogenase (MDH) were decreased in nicotine treated rats in the lung tissue and increases was observed in the combination treatment (Ni+RGEt) rats in both age groups. But at 25 mg/kg body weight were found more effective in both age groups. The Lactic dehydrogenase (LDH) activity was increased in all treated rats in the lung tissue then the control in both age groups, in nicotine treated rats in both age groups it is found more. This results stating that red grape extract treated rats are beneficial, especially for the nicotine subjects to improve the oxidative enzymes and thereby to improve the health status and life span.

Keywords: Nicotine, Red Grape extract, SDH, MDH, ICDH, LDH, Lung tissue and Male albino rat.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2022 Issue has been successfully launched on 1 May 2022.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT