DESIGN, CONVENTIONAL AND MICROWAVE ASSISTED SYNTHESIS OF MOLECULAR HYBRIDS OF THIAZOL-2-AMINE CONTAINING FLAVONE / CHALCONE MOIETIES POSSESSING ANTIMICROBIAL PROPERTIES
K. K. Sivakumar*, A. Naveen Kumar, M. Munirathinam, I. Ponnilavarasan, A. Preedeep and A. S. Muthu Priya
ABSTRACT
Some thiazol-2-amino-chalcone hybrids and thiazol-2-amino-flavones hybrids have been designed, synthesized and characterized the structure by FT-IR, H1-NMR and Mass spectra. Their invitro antimicrobial effect was evaluated, revealing that chalcone hybrids with thiazol-2-amine (10a-d) have the potential antibacterial activities against all the screened four Gram Positive and Gram-negative bacteria as well as four fungal strains. Compound (10a) demonstrate Minimum Inhibitory Concentration (MIC) activities against E.Coli, K. Pneumoniae, S. albus and B. subtilis at 6.25 μg/mL. Compounds (10c & d) exhibit significant MIC activities against S. albus, B. subtilis and A. fumigates at 6.25 μg/mL. Among the synthesized compounds, chalcone bearing 2-amino-thiazole derivatives (10a-d) showed better antimicrobial activity (>50%) compare with flavone bearing 2-amino-thiazole derivatives (8a-d). Compound 8a, displayed equipotent antifungal activity as that of standard Clotrimazole and MIC at 12.5 μg/mL against C. albicans.
Keywords: Flavones, Chalcone, 2-Amino Thiazoles and Antimicrobial.
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