Abstract
DEVELOPMENT AND CHARACTERIZATION OF DONEPEZIL MICROSPHERES BY USING IONOTROPIC GELATION TECHNIQUE

Nimmala Shanthi*, Shaik Shahin1 and Bhargav Bhongiri

ABSTRACT

Donepezil used to treatment of hypertention. Development the controlled release Donepezil microspheres using polymers in various formulations. These microspheres developed by utilizing the ionotropic gelationmethod. This makes Donepezil a better candidate for the formulate of CR dosage forms.The formulated were examined by release rate of the drug and further perform the stability data for selected or optimized formulation. The work was aimed to develop the controlled release Donepezil microspheres.

Keywords: Donepezil, Ionotropic gelation, natural and synthetic polymers, microspheres, Franz diffusion cell, zero order kinetics.


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