European Journal of Biomedical and Pharmaceutical Sciences

PREVALENCE OF ANTI CARDIOLIPIN ANTIBODIES IN PATIENTS WITH SUSPECTED ANTI PHOSPOLIPID SYNDROME

Dr. Vidya S.*

ABSTRACT

Aim: To estimate the prevalence (overall and the individual by clinical event type) of anti cardiolipin antibody (IgG, IgM positivity) in patients with suspected anti phospolipid syndrome. Methodology: 572 consecutive patients referred for evaluation of suspected antiphospolipid syndrome were screened for anti cardiolipin antibodies (IgG and IgM) by ELISA. Correlation between the type of antibody and the clinical events was analyzed. Results: Of the 109 patients referred for fetal losses 21 (19%) were positive for anti cardiolipin anti bodies. Of the total 153 cases referred for arterial thrombosis, 20 (19%) were positive for anticardiolipin and of the 147 cases with venous thrombosis 7 (4%) were positive for anti cardiolipin antibodies. Out of the 48 cases with positivity 33 had IgM positivity, 20 had IgG positivity and 5 had both. Conclusion: All patients presenting with recurrent fetal losses and thromboembolic phenomena should be screened for antiphospolipid antibodies.

Keywords: Antiphosolipid syndrome, recurrent fetal loss, anticardiolipin antibody, venous thrombosis, arterial thrombosis.