HYPOURICEMIC PROPERTY OF THE SEMI-PURIFIED FLAVONOIDS FROM TALONG-TALONGAN (SOLANUM TORVUM LINN. FAMILY SOLANACEA) LEAVES
Daez R. S. S., Domingo J. E. D., *Gaza R. B. L. and Mariño P. L. R., Mylene Sevilla Andal, RPh, MS Pharm and Susan S. Montemayor, RPh, MS Pharm
ABSTRACT
Solanum torvum commonly called as Talong-talongan is a plant that is currently used in Cameeron ethnomedicine for treatment of anti-gout. This plant is said to have a presence of flavonoids which has both a sedative and a diuretic therapeutic effect. Gout is a form of rheumatic disease caused by deposits of uric; Flavonoids display pharmacological properties as cytoprotective and antioxidant agent. The contents of the flavonoid were extracted by macerating about 100 grams of the dried leaves were place in a 500mL glass jar and macerated with a 500mL of 80% Ethyl Alcohol for 48 hours. Samples are subjected to ICR mice, divided into five groups a negative control, which are no treatment, positive control which are administered with allopurinol, the 100mg/mL, 200mg/mL, 300mg/mL of Talong-talongan samples. After a week of induction of high protein diet an increase of blood uric acid level base line was observed. All treatment groups and positive control showed decrease in uric acid levels. Higher dosage can significantly cause injury to the kidney. Therefore the researchers conclude that the flavonoid extract from the Talong-talongan (Solanum torvum Linn. A family Solanaceae) leaves has potential hypouricemic property.
Keywords: Hyperuricemic, hypouricemic, flavonoids, uric acid, therapeutic effect.
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