FORMULATION AND EVALUATION OF COLON TARGETED TABLETS OF KETOPROFEN USING COMBINED pH AND MICROBIAL APPROACH
Hitesh Jain*, Meena Waghela, Swetal Dindod and D. B. Meshram
ABSTRACT
Objective: The objective of present research work is to drug targeting in colon by using combined pH and microbial triggered approach. Experimental work: Colon targeted tablets of ketoprofen were prepared by direct compression method using natural polymer sterculia gum and pH dependent polymer Eudragit S 100. Core tablets were formulated then coated with pH dependent polymers. The formulated batches were evaluated for their precompression and post compression properties. Amount of Sterculia gum and % coating level were optimized by 32 factorial design. The optimized batch (M5) was subjected for the short-term stability study at 40 ± 2°C with RH of 75% for a period of one month. Result and discussion: Optimized formulation M5 containing 30% of Sterculia gum and coated with Eudragit S100 at the level of 8% released less amount of drug in 9.18% at the end of 5 hrs and 98.25% at the end of 12 hrs. The drug release from optimized formulation M5 follows Hixon Crowell kinetic (R2=0.986). the result of stability study indicated no significant changes with respect to drug release. Conclusion: Sterculia gum with the coating level of 8% of Eudragit S-100 released the drug in sustained manner over a period of 12 hrs in colonic region. Therefore, combined pH and microbial triggered approach is potential approach for the treatment of rheumatoid arthritis by overcoming the demerits of individual approach.
Keywords: Colon targeted, Microbial flora, Ketoprofen.
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