Abstract
REVIEW ARTICLE: CONVENTIONAL & NOVEL APPROACHES FOR COLON DRUG DELIVERY SYSTEM

Prof. Anand D. Savkare* and Vishal K. Nikam

ABSTRACT

Colon targeted drug delivery system (CDDS) helps in treatment of wide range of local diseases like ulcerative colitis, crohns diseases, irritable bowel syndrome, chronic pancreatitis, colorectal cancer and also help in treating non- colonic condition as colon act as potential site for systemic absorption of several drugs . This article reveals need, advantage, problems of colon targeted drug delivery .Further review article provide a discussion on primary approaches including Transit time dependent, pH dependent, bacterial enzyme dependent colonic drug delivery system, pH & Time dependent DDS, pH & bacterial enzyme DDS. Newer approaches like colonic pressure controlled CDDS, Osmotic pressure controlled CDDS, Pulsatile colonic drug delivery system.

Keywords: CDDS, Eudragit, Transit Time, Lag Phase, Colonic Micro-flora.


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