European Journal of Biomedical and Pharmaceutical Sciences

BIOGENIC SYNTHESIS OF GOLD NANOPARTICLES (AUNPS) USING CROCUS SATIVUS AND BERBERIS LYCIUM EXTRACTS AND THEIR CHARACTERIZATION

Bilal Nasir Zargar*, Shah Khalid, Aparna Alia and P.N. Shrivastava

ABSTRACT

Biogenic synthesis, so-called Green synthesis is a promising tool for medicines and nanotechnology. In Biogenic synthesis we used natural reducing agents to synthesize nanoparticles. In the present studies gold nanoparticles (AuNPs) were synthesized by reducing gold chloride (Chloroauric acid) with the help of leaf and flower extracts of Berberis lycium and Crocus sativus respectively. Both the plant's extracts were highly effective to reduce Chloroauric acid into gold nanoparticles. This approach is simple, economic, stable and is synthesized in an eco-friendly mode to obtain a self-assembly of AuNPs. The nanoparticles obtained are characterized by UV–vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). Antibiotic resistance is the world’s major public healthcare problem. AuNPs particles play a vital role in nanobiotechnology as biomedicine against Drug-resistant bacteria. Several classes of antimicrobial nanoparticles (NPs) and nanosized carriers for antibiotics delivery have proved their effectiveness as alternative agents to combat the antimicrobial resistance experienced with conventional drugs. The Gold nanoparticals have many applications in biology and medicine due to their unique optical and physical properties. These versatile reagents can be used for biosensor development, as cellular probes, as drug delivery vehicles, or as optical contrast agents among others. The present research opens a new avenue for the green synthesis of nanomaterials.

Keywords: Biogenic synthesis, Green synthesis, nanotechnology, Berberis lycium, Crocus sativus, nanoparticles.