FORMULATION DEVELOPMENT AND EVALUATION OF TOPICAL CURCUMIN EMULGEL
Sujitha Bajjuri*, Dr. Vinod K. R. and Dr. G. Sudershan Goud
ABSTRACT
The objective of the present study is to develop formulation for topical curcumin emulgel with targeted drug delivery for the treatment of inflammation of skin. All the excipients were cheked for their compatability with the drug by FTIR. The emulgel was prepared by making the emulsion and then gellifying this by mixing with the gel. The polymers carbpol 940, HPMC and sodium alginate were used as gelling agents here. The prepared emulgels were evaluated for physical examination, pH, consistency, drug entrapment, ex vivo diffusion, skin deposition, skin irritation. All the formulations showed acceptable physical properties, pH, consistency, drug entrapment, drug diffusion, drug deposition and no irritation on skin. Skin deposition values are much higher than the Ex vivo diffusion values which is a desired effect as anti-inflammatory action of curcumin requires drug deposition within the skin layers. Here, the effects of type of gelling agent, concentration of both the oil phase and emulsifying agent were investigated. All the formulations were free from skin irritation. From this work, it can be concluded that the emulgel formulation can be an innovative and promising approach for the topical drug delivery of curcumin for the treatment of skin disorders like inflammation.
Keywords: Curcumin, Emulsion, gel, emulgel, consistency, diffusion, skin deposition, skin irritation.
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