Abstract
ANTIDIABETIC ACTIVITY OF SENECIO TENUIFOLIUS EXTRACTS IN ALLOXAN INDUCED DIABETIC RATS

Shaik Sadik, Zeeshan Afsar*, P Kiran and Ragini V.

ABSTRACT

The present study was carried out to investigate the anti-diabetic activity of different extracts of the leaf and stem portions of Senecio tenuifolius in alloxan induced diabetic rats. The animals were divided into five groups with six rats in each group and diabetes was induced by injecting alloxan intravenously at a dose of 55mg/kg. Group-1 were administered orally 5% tween 80 as diabetic control. Group-2 rats and administered standard drug Glibenclamide. Group-3 rats were treated orally with aqueous extract of the drug. Group-4 rats were treated orally with ethanolic extract of the drug and Group-5 was treated with chloroform extract of the drug. Results revealed that the aqueous extract of the plant exhibited maximum blood glucose level reduction at 12th hour at a dose of 250mg/kg. Phytochemical screening of the aqueous, ethanolic and chloroform extracts of Senecio tenuifolius revealed the presence of alkaloids, glycosides, flavonoids, tannins and saponins. Results from this study suggest that the aqueous extract of Senecio tenuifolius possesses good anti-diabetic activity and could be used for the management of diabetes and associated metabolic disorders.

Keywords: Senecio tenuifolius, alloxan, Glibenclamide and ethanolic.


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