European Journal of Biomedical and Pharmaceutical Sciences

WITHANIA COAGULANCE DUNAL (PANIR DODA) AND ITS ANTIDIABETIC EFFECT: A REVIEW

Nidhi Verma* and Mandip Goyal

ABSTRACT

Diabetes, a rising epidemic throughout the world, has no signs of abatement and remains one of the most challenging health problems. The development and progression of diabetes and associated vascular complications are largely precipitated by chronic hyperglycemia-induced oxidative stress. Though many Ayurvedic medicines have promising anti hyperglycemic effect, but researches are still going to find out cost effective, easily available safe medicine for diabetes, so that ailing society can get freedom from this disease, one among such new emerging drug for disease is Withania Coagulans. This drug may be a promising medicine for diabetes, due to the presence of free radical scavenging potential which might help to protect against oxidative damage of organs along with anti hyper glycemic and hypolipidimic effect. An animal study demonstrates that Withania coagulans corrects hyperglycemia and maintained antioxidant status and reduced the proinflammatory markers in kidney which may subsequently reduce the development and progression of renal injury in diabetes, However the translation of therapeutic efficacy in humans require further studies. A pub med database search revealed 49 Articles on entering key word Withania coagulans, 40 related articles are found from Google scholar, whereas dhara online reveals no results on entering the key word Withania coagulans. 2 full papers are searched from Ayujournal.org. In this review paper the chemical constituents and pharmacological properties of W. coagulans along with morphology and its therapeutic effects on animal model and clinical trials are presented by using these articles. Withania coagulans can be successfully used in the diabetic patients.

Keywords: Withania Coagulans, proinflammatory.