European Journal of Biomedical and Pharmaceutical Sciences

EARLY PREDICTION OF SEVERITY OF ACUTE PANCREATITIS BY PANC-3 CRITERIA

Kumar Sanjeev, Sharma Anuj* and Aditya Vikram J. R.

ABSTRACT

Background: Acute Pancreatitis is a common disease in clinical practice, developing due to sudden inflammation of Pancreas, and to a varied degree involving local tissues or distant organs in a systematic manner. Acute Pancreatitis may at times remain underdiagnosed at the extremes of clinical spectrum of very mild and very severe disease. Failure to diagnose a fulminant attack can result in otherwise preventable mortality. Aim: To analyze simplified stratification system of PANC-3 criteria and compare it with APACHE-II for early prediction of severity of Acute Pancreatitis. Method: In this Prospective, Observational study 63 patients were evaluated and admitted with diagnosis of Acute Pancreatitis. Investigations were done on all patients and PANC-3 & APACHE-II scores were calculated. Results: PANC-3 score showed Sensitivity, 42.85%; Specificity, 100%; Positive Predictive Value, 100%; Negative Predictive Value, 85.96%; and Diagnostic Accuracy, 87.30%. Conclusion: Basal Metabolic Index(BMI), Hematocrit & Pleural Effusion on plain chest radiographs are simple tests required to determine PANC-3 score & hence can be easily performed even at small peripheral centres, which is an advantage over classical scoring systems. Interpretation of PANC-3 criteria doesn`t require expertise and can be determined at the time of admission, thus resulting in earlier prediction of disease severity.

Keywords: PANC-3 criteria, APACHE-II scoring system, Severe Acute Pancreatitis.