European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF PUFA RICH OIL ON PLASMA TNF-ALPHA AND CALCIUM LEVELS IN TYPE 2 DIABETIC PATIENTS

Uma Shanmugasundaram*, Dr. Anitha Achuthan, Dr. Saravanan Selvaraj and Prakash Selvaraj

ABSTRACT

Glucose is a ubiquitous fuel in biology. When there is a lack of insulin secretion or cell resist to uptake glucose leads to Diabetes Mellitus (DM). Diabetes leads to both premature death and complications such as inflammation, blindness, amputations, renal disease and cardiovascular diseases. Many scientists put limits saturated fat intake at the top of the list because these fats are strongly linked with heart disease and Type 2 Diabetes Mellitus. Polyunsaturated fatty acids (PUFA‟s) cannot be synthesized in the body and it must be provided in the diet only. Generally plasma Tumor Necrosis factor alpha (TNF- alpha) levels increase in many inflammatory diseases. Plasma levels of TNF alpha and calcium levels were assessed in diabetic patients without PUFA therapy (n = 30), with PUFA therapy for 30 days (n = 30) and normal healthy individuals (n=30). The values were statistically analyzed using one-way analysis of variance (ANOVA) followed by Tukey's posthoc test for multiple comparison methods. The Significance level was kept at P<0.05. The TNF alpha levels significantly increased in both diabetic groups than the normal group, and TNF alpha levels was significantly decreased in the PUFA therapy group than the without PUFA therapy group. The serum calcium levels were assessed in this study, but there is no significant change between the groups. In conclusion the PUFA rich oil has the effect on the reduction of TNF alpha levels in diabetic patients.

Keywords: PUFA, TNF-alpha, Diabetes mellitus and HbA1c.