European Journal of Biomedical and Pharmaceutical Sciences

GC-MS PROFILING OF CLASSICAL SIDDHA DISTILLATE INJI DRAVAGAM

*Vinayak S., Gayatri R. and Anil Sundaresan

ABSTRACT

Background: Yacob Vaidhya Cinthamani is a classical siddha work which mentions several herbal distillates for a wide range of clinical conditions. The medicine which is prepared through distillation is termed as Theeneer or Dravagam in Siddha system. Inji Dravagam is a formulation prepared with fresh ginger juice and Ajowan seeds mainly given for gastro intestinal problems. Since research work in Theeneer medicines are limited but very crucial for its validity, the distillate is prepared with reference to the classical siddha texts and further carried out GC-MS studies to understand the biological picture of the drug. Aim and Objectives: To validate the efficacy of Inji Dravagam with GC-MS supportive studies. Materials and Methods: The distillate with the reference to the classical texts were selected and prepared as per the standard procedures. The sample was studied with GC-MS. Results and Conclusion: Inji Dravagam was colorless with pleasant aroma and pungent taste. The Gas chromatogram of Inji Dravagam revealed 15 prominent peaks with retention time ranging from 3.6 to 47.8. The predominant compounds belong to the class of fatty acid esters reported through GC-MS which have labeled pharmacological profile as a health promoter. The compounds may work in a synergistic mode for the intended broad spectrum activity of the drug to be used in a wide range of medical conditions. The clinical importance of Inji Dravagam as a rejuvinative is well supported with this preliminary studies. Apart from the indications mentioned in the siddha texts, the drug may possess significant Anti oxidant effects and cardio protective role on the basis of presence of these biocompounds.

Keywords: Yacob Vaidhya Cinthamani, Theeneer, Inji Dravagam, GC-MS.