Abstract
FORMULATION AND IN VITRO CHARACTERISATION OF ETODOLAC FLOATING MICROSPHERES

Md. Reshma*, Dr. M. Dhanalakshmi and D. Ramchakradhar

ABSTRACT

Gastroretentive dosage forms have potential for use as controlled- release drug delivery systems. The aim of the present study is formulation and characterization of floating microspheres using Etodolac as a model drug for the management of Etodolac is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. Floating microspheres were prepared by solvent evaporation technique using Sodium alginate, Guargum, and HPMC as release retarding polymers. The floating microspheres were evaluated for percentage yield (%), Mean particle size, drug content, drug entrapment efficiency, In vitro Buoyancy and in vitro drug release studies. Compatibility studies were performed by fourier transform infrared (FTIR) technique. The prepared microspheres showed prolonged drug release of 12 h. The optimized formulation (F4) showed better drug release 97.36% for 12 hours. It was concluded that developed floating microspheres of Etodolac offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.

Keywords: Etodolac, Floating Microspheres, Sodium alginate, Guargum and Hpmc.


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