Abstract
FORMULATION AND EVALUATION OF STAVUDINE CONTROLLED RELEASE MATRIX TABLETS

G. Haritha*, Dr. V. Uma Maheshwar Rao, K. Rajini, K. Haritha, Kanugula Vijaykumar and K. Vijay Kumar

ABSTRACT

The aim of the present work is to Formulate and Evaluate controlled release of stavudine matrix tablets used for treatment of HIV infection. Development of CR stavudine is proposed considering the adverse event profile and high fluctuation index of stavudine observed with IR dosage forms. In the present work, attempts were made to formulate and evaluate controlled release of matrix tablets of stavudine. Stavudine was subjected to preformulation studies, based on the results obtained Stavudine controlled release tablets were successfully formulated. Formulations prepared by wet granulation using HPMC and carbopol 934 as control release polymers showed desired in vitro release. Set of trials were formulated for which stavudine evaluated parameters (bulk density, tapped density, compressibility index, hausner’s ratio, weight, thickness, hardness) were found to lie within the specifications. Dissolution study was performed in USP type II apparatus at 100 RPM in 0.1 HCL for 2 hours followed by pH 6.8 phosphate buffer. From the results of the in vitro study it appears that the release of the Stavudine was significantly influenced by the characteristics of the polymer used.

Keywords: Stavudine, Natural and Synthetic Polymers, Direct Compression Technique, in Vitro Drug Release Studies.


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