Abstract
FORMULATION AND DEVELOPMENT OF VENLAFAXINE EXTENDED RELEASE ORAL MATRIX TABLETS

*G. Lakshmi Devi

ABSTRACT

The main objective of this research is to develop and characterize venlafaxine extended Release Oral Matrix Tablets. Venlafaxine oral tablet is used to treat depression (immediate-release tablet and extended-release tablet). The matrix tablets of venlafaxine hydrochloride are prepared by wet granulation method. in the present formulation, the API venlafaxine is taken 225mg in all the formulations. HPMC K4M, HPMC K15MCR, HPMC K100LV CR, HPMC E50 LV AND Acryl-EZE RSPO polymers were used as rate retarding agents in twelve formulations(F-1 to F-12). the objective of the present study was to develop tablets of various formulations of venlafaxine oral matrix tablets. and the powder blend showed satisfactory flow properties, compressibility. The compressed tablets were undergone for precompression and post compression studies. All the physical characteristics of the fabricated tablets were found to with in the acceptable limits. among the formulations studied, F1,F3,F5,H7 and F9 formulations drug release was very fast and 90% of the drug was released in first 12hrs only. further batches were prepared and F12 containing 1:8 ratio of Eudragit RSPO and HPMC E50LV showed extended release up to 24 hrs and releases 97.54% of drug. The release mechanisms were explored and explained by zero oeder, first order, higuchiand korsmeyer-peppas equations.primary ten formulations were prepared by using two variable amounts of four polymers, HPMC K4M(50 mg,100mg) in the formulations from F-1 to F-2, HPMC K15M CR(50 mg,100mg) in the formulations F3-F4, HPMC K100 LV(50 mg,100mg) in the formulations F5-F6, HPMC E50 LV(50 mg,100mg) in the formulations F7-F8 and Eudragits RSPO in the formulations F9-F10, then two formulations were prepared by using combination of HPMC E50 LV and Eudragit RSPO in the formulations F11-F12. among these 12 formulations F12 was selected as the optimized formulation of extended release tablets for 24 hrs.

Keywords: Acryl-EZE, Anti Depressant, Extended Release Oral Matrix Tablets, Wet Granulation.


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