Abstract
ANTI-TUMOR EFFECT OF GRAVIOLA AND/OR CRANBERRY AS A NATURAL ANTI-PROLIFERATIVE AGENT ON COLORECTAL CELL LINES (CACO-2)

Iman Hesham El-Khashab* and Nadia Noble Daoud Aniss

ABSTRACT

The purpose of this study was to examine the anti-tumor effect of Graviola and/ or Cranberry on colorectal cancer cell lines (Caco2). Graviola and/or Cranberry were obtained and tested in vitro for their anti-proliferative activity against the colorectal cell lines (Caco2) for 24h by the MTT cell viability assay. DNA fragmentation was assessed by gel electrophoresis. Trypan blue assay was performed to determine the viability of cells. DNA content and distribution in different stages of cells and cell death were measured by flow cytometry. The result of this study highlighted the anti-tumor effect of Graviola and or Cranberry on Caco2. Moreover IC50 concentration of Graviola alone or with Cranberry were able to inhibit more than half of the percentage of colorectal cancer cell lines indicating an interesting anti-proliferating activity of Graviola alone or with Cranberry. This study suggests that Graviola alone or with Cranberry could be used as a source of natural anti-proliferative agent and thus could be useful as anti-tumor agent against colorectal cancer cells and is worth further investigation.

Keywords: Colorectal cell lines- Graviola- Cranberry- anti-tumor – cell viability.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW AUGUST ISSUE PUBLISHED

    AUGUST 2020 Issue has been successfully launched on 1 August 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT