European Journal of Biomedical and Pharmaceutical Sciences

MARKERS OF TISSUE DAMAGE AS INDICATORS OF COMPLICATIONS OF PREECLAMPSIA IN PREGNANT SUDANESE WOMEN

Hafiz Ahmed Hobiel Ahmed*, Hani Yousif Zaki Tadros and Badreldin Elsonni Abdalla Mohamed

ABSTRACT

Background: Preeclampsia is a pregnancy-related syndrome, which still represents one of the major causes of maternal-fetal mortality and morbidity mainly in underdeveloped countries where its incidence and mortality rates
are higher. Aim: To evaluate the role of markers of tissue damage as indicators of complications of preeclampsia
in pregnant Sudanese women attending Wad-Medani Obstetrics and Gynecology Teaching Hospital. Material
and method: This was a cross-sectional (case-control) study carried out in preeclamptic pregnant Sudanese
women attending Wad-Medani Obstetrics and Gynecology Teaching Hospital. A total of 208 pregnant women
were enrolled in the study,111 patients and 97 women with normal pregnancy as controls, pregnant women
suffering from any systemic or endocrine disorder were excluded. We compared the serum levels of lactate
dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK), uric acid, and creatinine between
preeclamptic and controls. Result and conclusion: The study revealed an elevation in the levels of LDH
(P<0.0001), AST (P= 0.029), CK (P<0.0001), uric acid (P=0.001) and creatinine (P=0.006) in preeclamptic
women than controls. These levels might indicate the severity of the tissue damage in preeclamptic women.

Keywords: Preeclampsia; Oxidative Stress; Hypertension; Proteinuria.