European Journal of Biomedical and Pharmaceutical Sciences

DAILY USAGE DOSE OPTIMATION OF OINTMENT, EMULSION, AND OINTMENT-EMULSION COMBINATION OF SNAKEHEAD FISH (CHANNA STRIATA BLOCH) EXTRACT FOR WOUND HEALING STAGE II ON WISTAR STRAIN WHITE MALE RATS (RATTUS NORVEGICUS)

Mohamad Andrie and Wintari Taurina*

ABSTRACT

Wounds are physical injuries that cause tears and damage to skin tissue.[1] The basic principle of optimal wound healing to minimize tissue damage is by providing proper nutrition with moist wound healing environment to restore the function of damaged tissue.[2] Snakehead fish extract emulsion that were given orally and snakehead fish extract ointment that were given topically can accelerate the wound healing process on Wistar strain white male rats.[3, 4] This research aims to see the effect of variations in daily doses of the use of ointment, emulsion, and ointment-emulsion combination of snakehead fish extract on Wistar strain white male rats that were given acute wounds close stage II. Wistar strain white male rats divided into 9 groups. Analysis result with Post Hoc Test-LSD indicates that the frequency of topical use is more dominant than oral use. The higher the frequency of topical use, the better the healing of wounds. The best topical use occurs in group 9 (3 times a day ointment and 3 times a day emulsion). Topical use that provides the best wound healing effect at least 2 times a day. For oral use it is very dependent on the topical use of at least 2 times a day. In oral use, the higher the frequency of oral use, the higher the healing power of the wound.

Keywords: snakehead fish extract, emulsion, ointment, wound healing.