Abstract
USE OF CARDIAC BIOMARKERS FOR PREDICTION OF CORONARY HEART DISEASE IN FAMILY MEMBERS OF DIABETICS IN JOS NIGERIA

*Bot D. Y., Ezra K., Ezeike C., Olaniru O. B., Bot S. Y., Shindang J., Ekwempu A. I., Ojo E. O., Ede O. N. and Chundusu D.

ABSTRACT

Diabetes is known as a strong etiological source of Coronary Heart Disease (CHD). Family history of diabetes and heart disease are key risk factors of Diabetes Mellitus Type-2 (DMT2) and Cardiovascular Disease especially CHD. The underlying disorders in diabetes and CHD are scientifically and clinically linked to genetic predispositions, lifestyle and socioeconomic factors. This study aimed at assessing some biomarkers of CHD in people with family history of diabetes. A total of 160 participants: 120 (75%) with family history of diabetes and 40 (25%) without history of diabetes, were enrolled in the study. Plasma and serum from venous blood samples were used in spectrophotometric assaying for Fasting Plasma Glucose, Lipids (Total Cholesterol, Triglycerides, High Density Lipoprotein Cholesterol and Low Density Lipoprotein Cholesterol); while high sensitivity C - reactive protein (hs-CRP) was measured using Enzyme Linked Immunosorbent Assay (ELISA) technique. Anthropometric parameters: weight and height were taken for Body Mass Index (BMI) while Blood Pressure (BP), was taken using a sphygmomanometer and stethoscope. The results showed mean of: Age (21-40 years), Systolic and Diastolic Blood Pressure (127.5±19.43 and 85.0±4.5 respectively), Fasting Blood Sugar (5.01±1.15), BMI (26.6±5.98), Triglycerides (1.12±0.71), hs-CRP (6.7±2.78). BMI and BP were statistically significant (p<0.05) with age while all other parameters were not statistically significant (p>0.05). We concluded that there is risk of CHD in relations of Diabetics; and that the Framingham risk tools, BMI, Lipid Profile Ratios, Family history and CRP levels could be used routinely in predicting Coronary Heart Disease.

Keywords: Coronary heart disease; Family History; Diabetes mellitus; Genetics; Asymptomatic risk.


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