Abstract
ASSOCIATION BETWEEN THROMBOPOIETIN AND HAEMATOLOGICAL PARAMETERS IN WHOLE BLOOD TRANSFUSED SUBJECTS WITH CHRONIC KIDNEY DISEASE ATTENDING UNIVERSITY OF PORT-HARCOURT TEACHING HOSPITAL

Mbeera B. S.*, Ken-Ezihuo S. and Eze E. M.

ABSTRACT

Thrombopoietin (TPO) is the key hematopoietic growth factor regulating the production of platelets from bone marrow megakaryocytes and maintaining platelet hemostasis. It is not clear whether whole blood transfusion in chronic kidney disease subjects affect changes in thrombopoietin and hematological parameters. Anaemia is known to be a major complication in CKD. The aim of the study was to assess the association between thrombopoietin and some haematological parameters in subjects with chronic kidney disease (CKD) who previously had or had not received multiple blood transfusion. A total of one hundred and fifty two (152) subjects were recruited for this study. One hundred and twenty two (122) subjects were recruited from those confirmed with renal diseases from the Urology Department of the hospital. Thirty eight (38) subjects were non-transfused with blood and eighty four (84) subjects were multitransfused with blood. Thirty subjects were apparently healthy controls. Thrombopoietin (TPO) was determined by sandwich ELISA method while the full blood count was determined using haematology autoanalyser, Mindray BC-5800. The results were statistically analysed using GraphPad prism version 5.0 and statistical significance set at P<0.05. A significant increase (p<0.0001) in TPO in the multitransfused 5.85±3.58 pg/ml compared to non-transfused and control subject 1.13±0.52 pg/ml, 1.15±0.36 pg/ml was observed. The significant increase in thrombopoietin may probably have been triggered by the transfusion of blood in the subjects that took blood transfusion. There was a positive and non-significant correlation between TPO and PCV (r = 0.011; p = 0.921), Hb (r = -0.066; p = 0.866), MCHC (r = 0.063; p = 0.564), MCV (r = 0.055; p= 0.618), PLT (r = 0.125; p = 0.257) respectively. It is concluded that transfusion enhances stimulation of thrombopoietin production but does not improve anaemia in CKD subject. It is therefore recommended that thrombopoietin assessment be properly checked in all CKD patients as this shall further aid the diagnosis of haematological characteristics in CKD since a known inverse relationship exist between thrombopoietin (TPO) and platelets.

Keywords: Thrombopoietin, haematological parameters, Chronic Kidney Disease, Blood Transfusion, Port-Harcourt.


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